Residual Neuromuscular Blockade: A Persistent Clinical Problem
نویسندگان
چکیده
منابع مشابه
Residual neuromuscular blockade: a persistent clinical problem.
In the classic study of deaths associated with anesthesia and surgery, Beecher and Todd in 1954 reported a 6-fold increase in the death rate of patients undergoing general anesthesia when ‘‘curare’’ was used compared with anesthesia without neuromuscular blockade (NMB). Their study must be viewed in the context of the initial use of neuromuscular blocking drugs (NMBDs) (curare) with volatile an...
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Neuromuscular blockade is a pharmacological adjunct for anesthesia and for surgical interventions. Neuromuscular blockers can facilitate ease of instrumentation and reduce complications associated with intubation. An undesirable sequela of these agents is residual neuromuscular blockade. Residual neuromuscular blockade is linked to aspiration, diminished response to hypoxia, and obstruction of ...
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Neostigmine has been traditionally used as the agent of choice to reverse Neuromuscular Blockade (NMB) after muscle paralysis during general anesthesia. However, the use of neostigmine has not been without untoward events. Sugammadex is a novel drug that selectively binds to aminosteroid nondepolarizing muscle relaxants and reverses even a deep level of NMB. Controversy exists regarding the opt...
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Muscle relaxants are routinely administered during anesthesia. The residual effects of nondepolarizing muscle relaxants must be reversed by the anesthesia provider prior to extubation of the trachea to ensure that patients can safely protect their own airways and maintain adequate ventilation. Many factors can potentiate the effects of muscle relaxants, and each of these factors must be taken i...
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ژورنال
عنوان ژورنال: International Anesthesiology Clinics
سال: 2006
ISSN: 0020-5907
DOI: 10.1097/00004311-200604420-00005